PHARMACOLOGY OBJECTS:Autonomic Nervous System: Question Set

1. Drugs activating this receptor are used in treating asthma:
   1.   beta1 adrenergic
   2.   muscarinic cholinergic
   3.   beta2 adrenergic
   4.   nicotinic cholinergic
2. Epinephrine effects on the heart
   1.   increased rate
   2.   decreased contractility
   3.   coronary vasodilation
   4.   A & C
3. Receptor activation mainly responsible for positive inotropism:
   1.   alpha1
   2.   beta1
   3.   dopamine D1
   4.   muscarinic cholinergic
4. Epinephrine effects on respiration:
   1.   stimulation
   2.   inhibition
5. Activates alpha receptors
   1.   isoproterenol (Isuprel)
   2.   propranolol (Inderal)
   3.   phenylephrine (Neo-Synephrine)
   4.   terbutaline (Brethine)
6. Blocks cardiac isoproterenol effects
   1.   terbutaline (Brethine)
   2.   esmolol (Brevibloc)
   3.   atropine
   4.   mecamylamine (Inversine)
7. Alpha agonist: vasoconstriction and elevates blood pressure:
   1.   metoprolol (Lopressor)
   2.   methoxamine (Vasoxyl)
   3.   terbutaline (Brethine)
   4.   ipratropium (Atrovent)
8. Nerve terminal reuptake inhibitor
   1.   methoxamine (Vasoxyl)
   2.   cocaine
   3.   reserpine
   4.   timolol (Blocadren)
9. Alpha adrenoceptor COVALENT blocker:
   1.   propranolol (Inderal)
   2.   phenoxybenzamine (Dibenzyline)
   3.   phentolamine (Regitine)
   4.   pilocarpine (Pilocar)
10. Orthostatic (postural) hypotension
    1.   beta receptor activation
    2.   alpha receptor activation
    3.   alpha receptor blocker
    4.   dopamine receptor blockade
11. Norepinephrine pressor response blocked by:
    1.   mecamylamine (Inversine)
    2.   prazosin (Minipress)
    3.   atropine
    4.   propranolol (Inderal)
12. Bronchodilation
    1.   ipratropium (Atrovent)
    2.   timolol (Blocadren)
    3.   albuterol (Ventolin,Proventil)
    4.   A & C
13. Positive chronotropic effects of epinephrine:
    1.   increased SA nodal potassium current
    2.   beta1 receptor activation
    3.   mediated by G protein
    4.   B & C
14. Maximal ß-adrenergic receptor desensitization depends on:
    1.   receptor occupancy by agonists
    2.   an arrestin protein
    3.   receptor phosphorylation
    4.   A, B & C
15. Phase of the cardiac action potential that principally determine heart rate
    1.   phase 0
    2.   phase 4
    3.   phase 2
    4.   phase 3
16. Most likely to increase myocardial afterload
    1.   angiotensin converting enzyme inhibitor (decreases angiotensin II concentration)
    2.   propranolol (Inderal)
    3.   phenylephrine (Neo-Synephrine)
    4.   low-dose epinephrine
17. Pressor effects of epinephrine are blocked by this drug ("epinephrine reversal")
    1.   propranolol (Inderal)
    2.   phentolamine (Regitine)
    3.   phenylephrine (Neo-Synephrine)
    4.   metoprolol (Lopressor)
18. Decreases blood pressure
    1.   propranolol (Inderal)
    2.   mecamylamine (Inversine)
    3.   phentolamine (Regitine)
    4.   all of the above
19. Specific alpha2 receptor agonist
    1.   phenoxybenzamine (Dibenzyline)
    2.   propranolol (Inderal)
    3.   guanfacine (Tenex)
    4.   methoxamine (Vasoxyl)
20. Centrally-acting antihypertensive drug
    1.   nitroprusside sodium (Nipride)
    2.   clonidine (Catapres)
    3.   methoxamine (Vasoxyl)
    4.   captopril (Capoten)